Step 1: Close all applications related to Outlook. Thus, you can try to reset the navigation pane to solve this issue. The information store cannot be opened Outlook error may be caused by corrupted navigation pane settings.
Check if the information store cannot be opened Outlook error still exists. Now you have successfully turned off the compatibility mode.
Step 3: Uncheck Run this program in compatibility mode for: under the Compatibility mode section. Step 2: Find the “ Outlook.exe” file, right-click it to choose Properties and navigate to the Compatibility tab. Step 1: Navigate straight to Local Disk: C > Program Files > Microsoft Office > Office XX. The second method you can try is to switch off the compatibility mode for Outlook. Method 2: Uncheck the Compatibility Mode Option for Outlook Wait for the process to complete, check if the information store cannot be opened Outlook error disappears. Step 3: A Choose Profile window will pop up. Step 2: Next, type Outlook /safe and click OK. Step 1: Press the Windows key + R hotkey at the same time to open the Run dialog box.
The first way you can try is to open Outlook in Safe Mode. Read More Method 1: Start Outlook in Safe Mode
